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Int J Mol Sci. Polypodium Leucotomos Extract Supplement. A personal experience on 495 patients affected by several forms of psoriasis and its answer to the treatment with Anapsos (Polypodium leucotomos extract) is presented. doi: 10.1016/j.jaad.2017.01.044. Polypodium leucotomos (PL) is a natural extract from tropical fern leaves with potent antioxidant and anti-inflammatory properties. Can Polypodium leucotomosprevent wrinkles? doi: 10.3390/ijms17071026. Anticancer Res. Polypodium leucotomos is a tropical fern from Central and South America. Topical or Oral Administration With an Extract of Polypodium Leucotomos Prevents Acute Sunburn and Psoralen-Induced Phototoxic Reactions as Well as Depletion of Langerhans Cells in Human Skin Sunburn, immune suppression, photoaging, and skin cancers result from uncontrolled overexposure of human skin to solar ultraviolet radiation (UVR). © 2005-2020 Healthline Media a Red Ventures Company. Antioxidants help defend your cells from damage. It is sold primarily as a capsule and is found as an ingredient in many sun-blocking supplements. What you eat affects many aspects of health — including your skin. In Western medicine, commercial extracts of Polypodium leucotomos have been available since the 1970s. Another extract (Anapsos, ASAC Pharma) has been used safely for up to 5 months. TIZAN Polypodium Leucotomos Extract Powder Benefits It is an addition to the armamentarium against the damaging effects of UV radiation exposure. Based on the results of current studies, taking up to 480 mg of oral Polypodium leucotomos per day appears to be safe for most people. Polypodium leucotomos is a type of fern found in the American tropics and sub-tropics. Current research suggests that up to 480 mg a day of oral Polypodium leucotomos is safe for the general population, but more research is needed. And while we may not be there quite yet, thanks to an ingredient called polypodium leucotomos extract (or “PLE”), sun care is getting a pretty big boost. Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice. Commercial extracts of Polypodium leucotomos have been available since the 1970s. But how does a capsule help your skin protect itself? There are several health benefits of sunlight. Commercial extracts of Polypodium leucotomos, which are … It is sold primarily as a capsule and is found as an ingredient in many sun-blocking supplements. The powerful antioxidant formula in each HELIOCARE® capsule was developed by leading dermatology experts and is naturally derived from Polypodium leuctomos (Calaguala), a fern native to Central and South America that has been used for centuries as a remedy for skin-related conditions. Both its thin, green leaves and underground stems (rhizomes) have been used for medicinal purposes for centuries (1). It has a long history of use as a folk remedy in Honduras, where it is used for a wide variety of ailments. Polypodium has also been linked with several other health benefits. A study in 40 healthy adults who took a placebo or 240 mg of oral Polypodium leucotomos twice a day for 60 days found that only 4 participants in the treatment group reported occasional fatigue, headaches, and bloating. I could not find any research regarding this herb and lupus. Studies suggest that Polypodium leucotomos may be effective at preventing sun damage and inflammatory reactions to UV rays. The Health Benefits of Polypodium Leucotomos, Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Fast Delivery. What you eat can have a big effect on inflammation in your body. Our vegetarian, gluten-free formula has no artificial dyes or fillers. For its photoprotective benefits it is often recommended to take it orally 30 to 60 minutes prior to sun exposure, once or several times per day. People with eczema — an inflammatory condition marked by itchy and red skin — may benefit from using Polypodium leucotomos in addition to traditional steroid creams and oral antihistamine medications. Polypodium leucotomos (Phlebodium aureum) is a tropical fern high in antioxidants that’s available in capsules and topical creams. Emily Dashiell, ND, is a licensed naturopathic doctor who has worked in group and private practice settings over the last 15 years. Sun Protection in a Pill: The Photoprotective Properties of Polypodium Leucotomos Extract - PubMed The use of a systemic protective agent would provide significant advantages such as a more uniform coverage over the total body surface area, regardless of individual factors such as potency of the creams, amount applied, sweating, or bathing. The same study showed that skin cells that contained p53 — a protein that helps prevent cancer — increased by 63% (5). Antioxidants are compounds that fight free radicals, unstable molecules that damage cells and proteins in your body. While the research is still inconclusive, extracts of the tropical fern show promise for preventing sunburn. However, these issues were considered unrelated to the supplement (15). Does Polypodium leucotomos extract (PLE) qualify? [PMC free article] [Google Scholar] 10. This once aquatic plant learned to live on land and developed its own natural protection to free radicals. Still, more studies are needed. Polypodium leucotomos extract: a status report on clinical efficacy and safety. Certain antioxidant-packed foods contain the fuel you need to guard…, Melasma is a common skin condition characterized by gray-brown patches of skin on areas of the face exposed to the sun. Fernblock® PLE Technology — an exclusive antioxidant extract. A 6-month study in 105 children and teens with eczema found that those who took 240–480 mg of Polypodium leucotomos daily were significantly less likely to take oral antihistamines compared to those who did not take the supplement (9). We spoke to leading dermatologist and founder of Curology to break down the…, Many foods contain beneficial compounds that could help decrease the growth of cancer. Gonzalez S, Alcaraz MV, Cuevas J, Perez M, Jaen P, Alvarez-Mon M, Villarrubia VG. One polypodium leucotomos extract (Fernblock, Cantabria Farmaceutica) has been used safely for up to 2 days. There is currently no standard recommended dosage. Treatment of Vitiligo Vulgaris With Narrow-Band UVB and Oral Polypodium Le ucotomos Extract: A Randomized Double-Blind Placebo-Controlled Study, Orally Administered Polypodium Leucotomos Extract Decreases Psoralen-UVA-Induced Phototoxicity, Pigmentation, and Damageof Human Skin, Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review, Polypodium leucotomos extract: a status report on clinical efficacy and safety. It contains compounds that may fight inflammation and prevent skin damage. Polypodium leucotomos extract is generally well tolerated and safe with few side effects, according to a 2015 study published in the Journal of Drugs in Dermatology. Other studies suggest that the fern may protect against skin damage caused by the sun and prevent inflammatory reactions to sun exposure (10, 11, 12). Does Polypodium leucotomosprevent suntans? A 2004 study published in the Journal of the American Academy of Dermatology examined whether Polypodium leucotomos could reduce the side effects of PUVA treatment. She is in private practice in Santa Monica, California. Orally Administered Polypodium Leucotomos Extract Decreases Psoralen-UVA-Induced Phototoxicity, Pigmentation, and Damageof Human Skin. (PLE) is an acronym for Polypodim Leucotomos Extract. The name — often used in modern biomedicine — is technically a deprecated synonym for the plant name Phlebodium aureum. Topical applications are available as well. Polypodium leucotomos leaf extract has shown benefits when taken via oral supplementation, and even to a certain degree when applied topically. This effect was more pronounced in people with lighter skin. Polypodium leucotomos is POSSIBLY SAFE when taken by mouth or applied to the skin, short-term. There may be benefits of topical application as well. Polypodium leucotomos is a type of fern native to the tropical and subtropical regions of the Americas. Less than one month after the initiation of vandetanib, the patient developed a severe, painful sunburn after minimal sun exposure. Think the risk of sun damage is over after you come indoors? Read our, Medically reviewed by Lana Butner, ND, LAc, Medically reviewed by Casey Gallagher, MD, Medically reviewed by Arno Kroner, DAOM, LAc, Learn These Tips If You Want to Safely Use Nutritional Supplements. Another study in 57 adults who typically developed skin rashes after sun exposure found that over 73% of participants reported significantly less inflammatory reactions to the sun after taking 480 mg of Polypodium leucotomos daily for 15 days (14). Research analysis led by Kamal Patel. 2007;21.7: 942-950. doi: 10.1111/j.1468-3083.2006.02132.x, Middelkamp-Hup MA, Pathak MA, Parrado C, et al. 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